Failure of recombinant factor VIIa in a patient with severe polymicrobial sepsis and postoperative uncontrolled intraabdominal bleeding
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منابع مشابه
Failure of recombinant factor VIIa in a patient with severe polymicrobial sepsis and postoperative uncontrolled intraabdominal bleeding
BACKGROUND This report discusses a case of unsuccessful treatment with recombinant factor VIIa (rFVIIa) in off-label use. The need for international guidelines concerning the off-label use of rFVIIa is outlined as well as the need for methods to control the efficacy of rFVIIa objectively. CASE PRESENTATION 54 year old male with severe polymicrobial sepsis due to a perforated diverticulitis of...
متن کاملTreatment of bleeding in severe necrotizing pancreatitis with recombinant factor VIIa.
To the Editor:—Recombinant1 factor VIIa has recently been developed to reduce bleeding complications in hemophilic patients. After injury to the vessel wall, tissue factor (TF) is exposed to the circulating blood and forms complexes with already activated FVII (FVIIa). The complex TF-FVIIa initiates hemostasis at the site of injury by activating FX into FXa, thereby providing the first amount o...
متن کاملEfficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review.
BACKGROUND Recombinant activated factor VII (factor VIIa) is a prohemostatic agent that can be used for patients with complicated coagulation disorders. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients with a preexistent normal coagulation system but who experience serious bleeding, for example, after major surgery or trauma. DATA SOURCE...
متن کاملUse of recombinant factor VIIa in uncontrolled gastrointestinal bleeding after hematopoietic stem cell transplantation among patients with thrombocytopenia.
BACKGROUND AND OBJECTIVE Recombinant-activated factor VII (rVIIa) is a vitamin K-dependent glycoprotein that is an analog of the naturally occurring protease. It has an off-label use to control life-threatening bleeding that is refractory to other measures and was shown to decrease transfusion requirements. Gastrointestinal (GI) bleeding is a severe complication following hematopoietic stem cel...
متن کاملThe Use of Recombinant Coagulation Factor VIIa (NovoSeven ® ) in Severe Diverticular Bleeding
We report a 68-year-old man with sigmoid colon carcinoma who previously underwent an anterior resection. Five years later, he developed a severe diverticular bleeding which required multiple blood transfusions. He underwent an emergent low anterior colectomy with a right colostomy to protect the anastomosis. Nine days after the operation, he had another severe bleeding. Due to his elderly age a...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2007
ISSN: 1471-2334
DOI: 10.1186/1471-2334-7-34